TEALE FENNING

wolverine · Century Club Joined: 16 Jan 2007 Posts: 394

1. A count of greater than 10 000 cfu/ml is significant bacteriuria
2. Prevalence of asymptomatic bacteriuria can be up to 43% in elderly women
3. two thirds of recurrent UTI's are caused by the same organism as the primary one
4. Urethral catheters are associated with higher rates of infection than suprapubic catheters
5. Tamm-Horsfall protein is increased in the urine of patients with pyelonephritis
6. E.coli is the leading causative organism in hospital aquired infections followed by klebsiella and enterobacter
7. Cranberry juice and vaginal oestrogens has been proven to be effective in the prevention of recurrence in post-menopausal women
8. Regarding pregnancy the following are correctly paired: a. sulfonamides

kernicterus b. Nitrofurantoin

haemolytic anaemia c. erythromycin

cholestatic jaundice d. chloramphenicol

neonatal cardiovascular collapse

EMAK · Century Club Joined: 26 Nov 2006 Posts: 572

mridulaben · Posted: Mon Jan 22, 2007 9:38 am Post subject: Re: UTI

wolverine · Century Club Joined: 16 Jan 2007 Posts: 394

Any more offers?

rpwalavalkar · Teale Fenning Administrator Joined: 20 Jul 2006 Posts: 966

my answers are ....

1. FALSE
Significant bacteriuria has been historically defined as finding more than 10 raised to 5 colony-forming units per mL of urine.

2. FALSE
Asymptomatic bacteriuria occurs in up to 6% of healthy individuals. It affects 18% of people with diabetes (mostly women), and 20% of elderly individuals (more often women than men).

3. FALSE
i think 2/3 is too high.

4. FALSE
i think rates depend on the duration of catheterisation and not the type of catheterisation.

5. TRUE
The thick ascending limb of loop of Henle secretes a protein called Tamm-Horsfall mucoprotein (THMP) or uromodulin. THMP is a membrane protein that is principally located on the luminal surface of the cell membrane of the urothelium. The function of THMP is unclear. It may have some immunomodulatory activity and may protect against urinary tract infection. When this protein is concentrated at low pH, it forms gel.

6. TRUE

7. TRUE

8.
Nitrofurantoin & haemolytic anaemia..True

Haemolysis frequently occurs in Glucose-6-phosphate dehydrogenase deficient patients who take nitrofurantoin. Discontinuation of the drug will often reverse this effect. Nitrofurantoin is contraindicated in pregnant women at term (38-42 weeks gestation) and it should not be administered during labour or just prior to labour to avoid precipitation of haemolytic anaemia in the neonate (AFHS Drug Information, 1995). There is a theoretical risk of nitrofurantoin-induced haemolytic anaemia in the newborn of mothers with G-6-PD deficiency (D'Arcy, 1985). Neonates are at high risk of haemolysis induced by nitrofurantoin due to their immature enzyme systems (New Ethicals Catalogue, 1996).

erythromycin & cholestatic jaundice ..TRUE

ref--
Erythromycin estolate and jaundice. [Br Med J (Clin Res Ed). 1983] Erythromycin jaundice: diagnosis by an in vitro challenge test. [Aust N Z J Med. 1977]
Jaundice caused by erythromycin estolate [Policlinico [Prat]. 1969]
Hepatocellular jaundice due to erythromycin estolate [Harefuah. 1978] Studies on the vitro cytotoxicity of erythromycin estolate. [Proc Soc Exp Biol Med. 1973]

chloramphenicol & neonatal cardiovascular collapse -- TRUE

sulfonamides & kernicterus -- TRUE

Kernicterus may occur in the newborn as a result of treatment of a pregnant woman at term with orally administered sulfonamides. There are no adequate and well controlled studies of sulfonamide ophthalmic preparations in pregnant women and it is not known whether topically applied sulfonamides can cause fetal harm when administered to a pregnant woman.
Severe reactions to sulfonamides include STEVENS-JOHNSON syn, toxic epidermal necrolysis, fulminant hepatic necrolysis, agranulocytosis, aplastic anaemia.
_________________
Dr Miss. Raj Walavalkar MBBS MRCOG
TealeFenning Administrator
SR O&G Wessex Region

mridulaben · Posted: Tue Jan 23, 2007 9:41 am Post subject: Re: UTI

[quote="wolverine"]
1. A count of greater than 10 000 cfu/ml is significant bacteriuria- False, true for Bacteriuria
2. Prevalence of asymptomatic bacteriuria can be up to 43% in elderly women- TRUE( in evidence based byLUESLY & BAKER0
3. two thirds of recurrent UTI's are caused by the same organism as the primary one- FALSE<, it is one third
4. Urethral catheters are associated with higher rates of infection than suprapubic catheters- TRUE 9 according to SHAW"s textbook)

wolverine · Century Club Joined: 16 Jan 2007 Posts: 394

Now you are spot on mridulaben!!!
And all the drug associations are true as RAJ said