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tamoxifen

 
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rpwalavalkar
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Joined: 20 Jul 2006
Posts: 966

PostPosted: Thu May 01, 2008 9:39 am    Post subject: tamoxifen Reply with quote

T / F

Tamoxifen potentiates the anticoagulant effect of warfarin.

Is associated with Retinal damage.

Increases bone resorpiton in patients with bone metastasis and causes hypercalcemia.


[ Ref -- ABPI (Association of the British Pharmaceutical Industry) (1989)
Data Sheet Compendium. London. ]
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Dr Miss. Raj Walavalkar MBBS MRCOG
TealeFenning Administrator
SR O&G Wessex Region
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cpeedahsa
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Joined: 21 Apr 2007
Posts: 921

PostPosted: Thu May 01, 2008 4:41 pm    Post subject: Re: tamoxifen Reply with quote

rpwalavalkar wrote:
T / F

Is associated with Retinal damage.

[ Ref -- ABPI (Association of the British Pharmaceutical Industry) (1989)
Data Sheet Compendium. London. ]


True

Retinal damage and keratitis have been reported in patients after large cumulative doses of tamoxifen, generally over 180 mg per day for more than 1 year (Buckley & Goa, 1989), though sometimes with smaller doses (Griffiths, 1987).
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cpeedahsa
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Joined: 21 Apr 2007
Posts: 921

PostPosted: Thu May 01, 2008 4:43 pm    Post subject: Re: tamoxifen Reply with quote

rpwalavalkar wrote:
T / F

Tamoxifen potentiates the anticoagulant effect of warfarin.

[ Ref -- ABPI (Association of the British Pharmaceutical Industry) (1989)
Data Sheet Compendium. London. ]


True
Tamoxifen POTENTIATES the anticoagulant effect of warfarin, and this interaction can be life-threatening (Tenni et al, 1989; Ritchie & Grant, 1989).


Last edited by cpeedahsa on Thu May 01, 2008 4:50 pm; edited 1 time in total
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cpeedahsa
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Joined: 21 Apr 2007
Posts: 921

PostPosted: Thu May 01, 2008 4:50 pm    Post subject: Re: tamoxifen Reply with quote

rpwalavalkar wrote:
T / F

Increases bone resorpiton in patients with bone metastasis and causes hypercalcemia.

[ Ref -- ABPI (Association of the British Pharmaceutical Industry) (1989)
Data Sheet Compendium. London. ]


True
In about 15% of patients with bone metastases, tamoxifen causes tumor flare-up resulting in hypercalcemia
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