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rpwalavalkar Teale Fenning Administrator
Joined: 20 Jul 2006 Posts: 966
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Posted: Thu May 01, 2008 9:39 am Post subject: tamoxifen |
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T / F
Tamoxifen potentiates the anticoagulant effect of warfarin.
Is associated with Retinal damage.
Increases bone resorpiton in patients with bone metastasis and causes hypercalcemia.
[ Ref -- ABPI (Association of the British Pharmaceutical Industry) (1989)
Data Sheet Compendium. London. ] _________________ Dr Miss. Raj Walavalkar MBBS MRCOG
TealeFenning Administrator
SR O&G Wessex Region |
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cpeedahsa Century Club
Joined: 21 Apr 2007 Posts: 921
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Posted: Thu May 01, 2008 4:41 pm Post subject: Re: tamoxifen |
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| rpwalavalkar wrote: | T / F
Is associated with Retinal damage.
[ Ref -- ABPI (Association of the British Pharmaceutical Industry) (1989)
Data Sheet Compendium. London. ] |
True
Retinal damage and keratitis have been reported in patients after large cumulative doses of tamoxifen, generally over 180 mg per day for more than 1 year (Buckley & Goa, 1989), though sometimes with smaller doses (Griffiths, 1987). |
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cpeedahsa Century Club
Joined: 21 Apr 2007 Posts: 921
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Posted: Thu May 01, 2008 4:43 pm Post subject: Re: tamoxifen |
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| rpwalavalkar wrote: | T / F
Tamoxifen potentiates the anticoagulant effect of warfarin.
[ Ref -- ABPI (Association of the British Pharmaceutical Industry) (1989)
Data Sheet Compendium. London. ] |
True
Tamoxifen POTENTIATES the anticoagulant effect of warfarin, and this interaction can be life-threatening (Tenni et al, 1989; Ritchie & Grant, 1989).
Last edited by cpeedahsa on Thu May 01, 2008 4:50 pm; edited 1 time in total |
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cpeedahsa Century Club
Joined: 21 Apr 2007 Posts: 921
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Posted: Thu May 01, 2008 4:50 pm Post subject: Re: tamoxifen |
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| rpwalavalkar wrote: | T / F
Increases bone resorpiton in patients with bone metastasis and causes hypercalcemia.
[ Ref -- ABPI (Association of the British Pharmaceutical Industry) (1989)
Data Sheet Compendium. London. ] |
True
In about 15% of patients with bone metastases, tamoxifen causes tumor flare-up resulting in hypercalcemia |
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