TEALE FENNING Medical Education    FAQ   Search   Memberlist   Usergroups   Register   Profile   Log in to check your private messages   Log in  mrcog courses for doctors megaloblastic anemia in pregnency is associated with          TEALE FENNING Forum Index -> MRCOG Part 2: MCQ & Past Paper questions View previous topic :: View next topic   Author Message farha Century Club Joined: 18 May 2007 Posts: 156 Posted: Sat Apr 19, 2008 7:10 pm    Post subject: megaloblastic anemia in pregnency is associated with 1) more rapid fal lin haemoglobin level than in microcytic anemia 2)risk nnof subacute combined degeneration 3prompt response to hydroxycobalmin 4)can cause myotonic dystrophy 5)could be because of maternal coeliac disease 6)could be because of beta thalssaemia 7)The presence of circulating antibodies to perietal cells Back to top cpeedahsa Century Club Joined: 21 Apr 2007 Posts: 921 Posted: Sat Apr 19, 2008 8:15 pm    Post subject: Re: megaloblastic anemia in pregnency is associated with farha wrote: 6)could be because of beta thalssaemia False Peripheral blood picture in beta thalassemia is Isolated, mild microcytic anemia, target cells on the peripheral blood smear, and a normal red blood cell count. Back to top cpeedahsa Century Club Joined: 21 Apr 2007 Posts: 921 Posted: Sat Apr 19, 2008 8:24 pm    Post subject: Re: megaloblastic anemia in pregnency is associated with farha wrote: 5)could be because of maternal coeliac disease True Anemia is the most common laboratory manifestation of celiac disease. One half of patients with newly diagnosed gluten-sensitive enteropathy are anemic. Iron is absorbed in the proximal small intestine, where celiac manifestations are most prominent; hence, iron malabsorption is common. In addition, occult blood loss related to intense small-bowel inflammation may occur in 50 percent of patients with gluten-sensitive enteropathy Less commonly, vitamin B12 deficiency, folate deficiency, or both may be present. Back to top cpeedahsa Century Club Joined: 21 Apr 2007 Posts: 921 Posted: Sat Apr 19, 2008 8:44 pm    Post subject: Re: megaloblastic anemia in pregnency is associated with farha wrote: 7)The presence of circulating antibodies to perietal cells Actually, again wording of the question. Question particularly referring to Megaloblastic Anemia of Pregnancy --- Some textbooks and other published literature actaully refer to Folic Acid Deficiency Anemia as Megaloblastic Anemia of Pregnancy . In that case the answer is False If we are just talking about Megaloblastic anemia --then yes , although very rare it can be associated with circulating antibodies to parietal cells and the answer would be True Parietal cell antibody is present in the sera of almost 90% of adult patients with Pernicious anemia and pernicious anemia cause of Vitamin B12 deficiency Megaloblastic anemia Last edited by cpeedahsa on Sat Apr 19, 2008 9:10 pm; edited 3 times in total Back to top cpeedahsa Century Club Joined: 21 Apr 2007 Posts: 921 Posted: Sat Apr 19, 2008 8:51 pm    Post subject: Re: megaloblastic anemia in pregnency is associated with farha wrote: 4)can cause myotonic dystrophy FalseMyotonic dystrophy is an autosomal dominant inherited disorder Back to top cpeedahsa Century Club Joined: 21 Apr 2007 Posts: 921 Posted: Sat Apr 19, 2008 9:07 pm    Post subject: Re: megaloblastic anemia in pregnency is associated with farha wrote: 3 prompt response to hydroxycobalmin False Prompt response only in case of megaloblastic anemia due to Vit B12 deficiency. And the msot common casue of megaloblastic anemia in pregancy is folic acid deficiency. Back to top cpeedahsa Century Club Joined: 21 Apr 2007 Posts: 921 Posted: Sat Apr 19, 2008 9:08 pm    Post subject: Re: megaloblastic anemia in pregnency is associated with farha wrote: 2)risk nnof subacute combined degeneration Specifically about megaloblastic anemia in pregnancy So False Back to top cpeedahsa Century Club Joined: 21 Apr 2007 Posts: 921 Posted: Sat Apr 19, 2008 9:11 pm    Post subject: Re: megaloblastic anemia in pregnency is associated with farha wrote: 1) more rapid fal lin haemoglobin level than in microcytic anemia False Hemoglobin falls more rapidly in case of Iron deficiency/blood loss-- Microcytic anemia Back to top farha Century Club Joined: 18 May 2007 Posts: 156 Posted: Sun Apr 20, 2008 5:11 am    Post subject: megaloblastic anemia in pregnency is associated with perfect asha but i was really thinking about no 2 as i posted that in RCOG foru due to little doubt and response from all those who have cleared MRCOG was TRUE .Perhaps RAJ and NICK can throw some light Back to top cpeedahsa Century Club Joined: 21 Apr 2007 Posts: 921 Posted: Sun Apr 20, 2008 5:58 am    Post subject: Re: megaloblastic anemia in pregnency is associated with farha wrote: perfect asha but i was really thinking about no 2 as i posted that in RCOG foru due to little doubt and response from all those who have cleared MRCOG was TRUE . Subacute combined degeneration (SCD) of the spinal cord is a characteristic complication of vitamin B12 deficiency And Megaloblastic Anemia of pregnancy is mainly due to Folic acid deficiency Back to top Nick Raine-Fenning Course Director Joined: 27 May 2006 Posts: 1852 Location: Nottingham Posted: Mon Apr 21, 2008 6:01 am    Post subject: This is a difficult one and it all depends on the minset of the person who wrote the question. The way the questions are worded in the Past Paper book made me think they were talking about B12 deficiency. It seems silly to ask you so many detailed quetions about B12 deficiency (SCAD, parietal cell antibodies etc) only as a trick! The RCOG are not supposed to write trick questions. There are two key issues here: 1. what is the most common cause of megaloblastic anaemia in pregnancy 2. is the College referring to folate deficiency or B12 I know they seem inseparable but I wonder if they are!! Question 1 is the most important as it makes the answers all false or all true with the exception of rapid onset which is false for both folate and B12 deficiency. 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