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Management of acute appendicitis in pregnancy
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Xerxes I
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PostPosted: Sat Mar 29, 2008 8:28 am    Post subject: Management of acute appendicitis in pregnancy Reply with quote

It's a made up EMQ

a) Appendicectomy through pfannenstiel followed by a caesarean section
b) Appendicectomy through Mcburney's incision and await normal onset of labour for NVD
c) Appendicectomy through an incision over the maximum pain point and await normal onset of labour for NVD
d) Appendicectomy through an incision over the maximum pain point followed by induction of labour


26 yo, Primip, generally fit and well, uncomplicated pregnancy previously, well grown baby and normal CTG. T: 38.1, peritonism, WCC 28.9. Appendicitis is highly likely and a decision for appendicectomy has been made jointly by surgeons and obstetricians, both teams are available for operation.

1/ 39 weeks appendix looks normal
2/ 39 weeks and appendix is found to be ruptures with pus insude abdomen
3/ 39 weeks, appendix inflamed
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cpeedahsa
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PostPosted: Sat Apr 19, 2008 10:03 pm    Post subject: Re: Management of acute appendicitis in pregnancy Reply with quote

Xerxes I wrote:
It's a made up EMQ

a) Appendicectomy through pfannenstiel followed by a caesarean section
b) Appendicectomy through Mcburney's incision and await normal onset of labour for NVD
c) Appendicectomy through an incision over the maximum pain point and await normal onset of labour for NVD
d) Appendicectomy through an incision over the maximum pain point followed by induction of labour


26 yo, Primip, generally fit and well, uncomplicated pregnancy previously, well grown baby and normal CTG. T: 38.1, peritonism, WCC 28.9. Appendicitis is highly likely and a decision for appendicectomy has been made jointly by surgeons and obstetricians, both teams are available for operation.

1/ 39 weeks appendix looks normal


Ans:c) Appendicectomy through an incision over the maximum pain point and await normal onset of labour for NVD
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cpeedahsa
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PostPosted: Sat Apr 19, 2008 10:04 pm    Post subject: Reply with quote

Treatment of appendicitis is surgical. Perform surgery as soon as the diagnosis is seriously considered. Either laparotomy or laparoscopy can be performed.

Even if the appendix appears normal, there are 2 reasons to remove it: (1) early disease may be present despite its grossly normal appearance and (2) diagnostic confusion can be avoided if the condition recurs.

Most authorities suggest a right midtransverse incision directly over the point of maximal tenderness.

Some suggest a lower abdominal midline incision to accommodate unexpected surgical findings and the possibility of the need for cesarean delivery.

Tailor the surgical approach to the clinical situation.

Tilt the operating table 30° to the patient's left to help bring the uterus away from the surgical site and to improve maternal venous return and cardiac output.
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cpeedahsa
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PostPosted: Sat Apr 19, 2008 10:05 pm    Post subject: Re: Management of acute appendicitis in pregnancy Reply with quote

Xerxes I wrote:
It's a made up EMQ

a) Appendicectomy through pfannenstiel followed by a caesarean section
b) Appendicectomy through Mcburney's incision and await normal onset of labour for NVD
c) Appendicectomy through an incision over the maximum pain point and await normal onset of labour for NVD
d) Appendicectomy through an incision over the maximum pain point followed by induction of labour


26 yo, Primip, generally fit and well, uncomplicated pregnancy previously, well grown baby and normal CTG. T: 38.1, peritonism, WCC 28.9. Appendicitis is highly likely and a decision for appendicectomy has been made jointly by surgeons and obstetricians, both teams are available for operation.


2/ 39 weeks and appendix is found to be ruptures with pus insude abdomen
3/ 39 weeks, appendix inflamed


Ans:c) Appendicectomy through an incision over the maximum pain point and await normal onset of labour for NVD

in all the 3 cases
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Xerxes I
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PostPosted: Sun Apr 20, 2008 6:41 am    Post subject: Reply with quote

She is 39 weeks, is it ok for her to push, say 2 days after her appendicectomy? Don't know the answer, just asking Confused
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rpwalavalkar
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PostPosted: Sun Apr 20, 2008 6:45 am    Post subject: Reply with quote

some other points --

negative laparotomy rate is 15 -35 %
at laparotomy diagnostic accuracy is about 50%

in first trimester laparoscopy is an option.

at laparotomy incision over point of max tenderness because -- as the uterine size increases the appendix is displaced above the McB's point with horizontal rotation of it's base. this migration continues till 8th month when 90% of appendix lie above the iliac crest and 80% rotate upwards and towards the rt sub-costal area.

preterm labour occurs in 1-5% of uncomplicated appendicitis.
ruptured appendix -- foetal loss is up to 30%


ref --

A De Cherney, L Nathan, M Pernoll. Surgical Diseases and Disorders in Pregnancy. Current obstetric and gynaecologic diagnosis and treatment. ISBN:0838514014
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cpeedahsa
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PostPosted: Sun Apr 20, 2008 7:21 am    Post subject: Reply with quote

Xerxes I wrote:
She is 39 weeks, is it ok for her to push, say 2 days after her appendicectomy? Don't know the answer, just asking Confused


I think it should be OK for her to push. Not sure, but if you are referring to say...wound dehiscence--I guess we just take care of it, if it happens.
I would not recommend C.Section just based on this.

Current Diagnosis & Treatment Obstetrics & Gynecology - 10th Ed. (2007) says this about appendectomy in pregnancy
Labor that follows shortly after surgery in the late third trimester should be allowed to progress because it is not associated with a significant risk of wound dehiscence.

The decision for C.Section is seldom/unusually made-- it also depends on the clinical picture--say for example if severe peritonitis, sepsis, or a large appendiceal or cul-de-sac abscess is seen on opening abdomen.

IN the question-- appendix looks normal (I presume it is on ultrasound)(although clinically peritonism). In case of severe doubt and inconclusive US, some go for an MRI before planning surgery( to decide which incision).(CT is OK too) but with peritonism -- waiting can be dangerous)
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cpeedahsa
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PostPosted: Sun Apr 20, 2008 7:39 am    Post subject: Reply with quote

A Smead-Jones closure with secondary wound closure 72 hours later may be advisable when the appendix is gangrenous or perforated or in the presence of peritonitis or abscess formation.
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rpwalavalkar
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PostPosted: Sun Apr 20, 2008 7:44 am    Post subject: Reply with quote

Xerxes I wrote:
She is 39 weeks, is it ok for her to push, say 2 days after her appendicectomy? Don't know the answer, just asking Confused



yes it is ok to push.

ref -- same as from my post above.
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cpeedahsa
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PostPosted: Sun Apr 20, 2008 7:47 am    Post subject: Reply with quote

Regarding tocolysis ( not for the case mentioned above)

Data are limited, so making definitive recommendations regarding the use of prophylactic tocolytics is difficult. Caution is indicated because of reports that tocolytics are associated with an increased risk of pulmonary edema in women with sepsis.

Wlliams Obstetrics says this-
Quote:
Uterine contractions are common, and although some clinicians recommend tocolytic agents, we do not.


Last edited by cpeedahsa on Sun Apr 20, 2008 7:48 am; edited 1 time in total
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cpeedahsa
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PostPosted: Sun Apr 20, 2008 7:48 am    Post subject: Reply with quote

If appendicitis is undiagnosed before delivery, often when the large uterus rapidly empties, walled-off infection is disrupted causing an acute surgical abdomen.

New-onset appendicitis during the immediate puerperium is very uncommon simply because of chance. It is important to remember that puerperal pelvic infections typically do not cause peritonitis.

Ref:Williams
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rpwalavalkar
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PostPosted: Sun Apr 20, 2008 7:55 am    Post subject: Reply with quote

about tocolysis --

we had a case of acute appendicitis in preg at 33 weeks some time back. my consultants preferred not to give tocolysis, cover with antibiotics and steroids and deliver by LSCS 24 hrs later, did appendisectomy at the same sitting.

the logic was that deli better than conservative Mx and the gravid ut may contain spread of infection even if appendix bursts + pt already under Abx cover.

the problem usually faced is to decide when to deliver. with the above case it made sense not to wait.

have also read about the risk of pulm oedema if sepsis present and if tocolysis given
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Xerxes I
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PostPosted: Sun Apr 20, 2008 8:30 am    Post subject: Reply with quote

So in this case (ruptures Appendix) where pressumably there will be acute abdomen and pus everywhere, would you close and await normal onset of labour or would you section?
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rpwalavalkar
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PostPosted: Sun Apr 20, 2008 8:50 am    Post subject: Reply with quote

LSCS under strong antibiotic cover. the foetal mortality can be as high as 30% so better to section
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cpeedahsa
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PostPosted: Sun Apr 20, 2008 12:02 pm    Post subject: Reply with quote

Xerxes I wrote:
So in this case (ruptures Appendix) where pressumably there will be acute abdomen and pus everywhere, would you close and await normal onset of labour or would you section?


Pus everywhere in the abdomen-- good reason not to open the uterus abdominally.

One would have to balance the risks of opening the uterus in a septic area... risk of endometritis, the risk of a uterine scar, the woman's general condition, obstetrics history, course of this pregnancy, will she be able to sustain labor v/s C.Section.

As always, in such situations-- consult the patient , discuss the issues, offer them the options and let them decide CS v/s VD.

In a septic abdomen I would not do a C.Section, if I can avoid it.

Broad-spectrum intravenous antibiotics anaerobic coverage are appropriate in the presence of perforation, peritonitis, or abscess formation.

Evidence suggests it is the delay in surgical intervention that carries increased risk of fetal loss as is preterm labor.

Current diagnosis in O & G
Quote:
Perinatal loss may occur in association with preterm labor and delivery or with generalized peritonitis and sepsis, occurring in 0–1.5% of uncomplicated appendicitis cases. With appendiceal rupture, fetal loss rates are reportedly as high as 30%. This is of particular concern because appendiceal rupture occurs most frequently in the third trimester. Thus it is imperative to avoid surgical delay.
suggests-- Arrow needs early surgery for appendicitis.


Prophylactic antibiotic therapy otherwise ( in uncomplicated appendicitis)is controversial.
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Xerxes I
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PostPosted: Sun Apr 20, 2008 12:27 pm    Post subject: Reply with quote

Exactly, However, Raj's argument is also valid. That's why I wrote the questions seperately depening on the findings of laparotomy.

If you do proper washing, and when you've got good antibiotic cover and have removed the source of infection, infectious environment should be less of an issue but I agree that it is still a bit dodgy, if that's the right medical term.

I also agree that high risk of fetal loss is probably due to the delay in surgery and subsequent poor maternal condition and severe infection in the abdomen,, etc. When you have treated the cause, there should be no reason for the baby to die more that it would after a laparotomy.

But these are all assumptions and not backed by RCTs Twisted Evil I think it is perfectly reasonable to use your common sense. in this situation.

For exam purposes, I liked your paragraph about balancing ..., always the right thing to say.
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Xerxes I
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PostPosted: Sun Apr 20, 2008 12:37 pm    Post subject: Reply with quote

About the balancing paragraph (and I think there should be one in EVERY essay) I would say something like:

A caesarean section in this situation is best avoided if at all possible. The risk of opening the uterus in an infectious environment and creating a uterine scar should be balanced against the potential benefits of avoiding probable higher risk of perinatal mortality if undelivered.

If a caesarean section was necessary (for example for fetal distress), meticulous pelvic washing should be performed prior to opening the uterus and broad spectrum antibiotics etc. drain should be considered.
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cpeedahsa
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PostPosted: Sun Apr 20, 2008 1:31 pm    Post subject: Reply with quote

Xerxes I wrote:
About the balancing paragraph (and I think there should be one in EVERY essay) I would say something like:

Arrow A caesarean section in this situation is best avoided if at all possible. The risk of opening the uterus in an infectious environment and creating a uterine scar should be balanced against the potential benefits of avoiding probable higher risk of perinatal mortality if undelivered.

Arrow If a caesarean section was necessary (for example for fetal distress), meticulous pelvic washing should be performed prior to opening the uterus and broad spectrum antibiotics etc. drain should be considered.


Totally agree with the your second paragraph about meticulous wash etc.

Regarding the first--the higher risk of perinatal mortality is due to delay in surgery for appendicitis. While there is evidence that early surgery for appendicitis decraeses risk of perinatal mortality--as of now, there is no evidence as of now that C.Section will improve perinatal mortality. Maybe we could write-- discussion with the couple and offering them options and allowing them to decide.
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cpeedahsa
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PostPosted: Sun Apr 20, 2008 1:37 pm    Post subject: Reply with quote

all in all, Beautiful scenario Xerxes I .

Was it a real scenario? It would make a very good case report.
"Dilemma in Management of Appendicitis in Pregnancy-Case Report and Review of literature".. Xerxes et al.... Very Happy

We can quote your publication next time we try to answer a question on Appendicitis in Pregnancy
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Xerxes I
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PostPosted: Sun Apr 20, 2008 2:16 pm    Post subject: Reply with quote

I am going to say a very unscientific thing:

If it was my wife, I would convince her to have a caesarean at laparotomy. Evidence or no evidence, I don't want my baby anywhere near severe inflammation and intraabdominal pus. It just feels better. If she woke up after the laparotomy and says: but is it not dangerous for the baby to be in there? I can see how she'd look at me if I go: but darling, there is no evidence....

What you are saying is perfectly sensible but it doesn't feel right to me. On the other hand, no evidence of harm is not the same as evidence of no harm. There will be no RCTs comparing conservative management at term after ruptured appendicectomy and pus in the tummy with caesarean.

Have I told you about Prof. Smith's Parachute analogy?
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