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cpeedahsa
Century Club
Joined: 21 Apr 2007
Posts: 922
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 Posted: Tue Sep 09, 2008 8:29 pm Post subject: |
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| Nick Raine-Fenning wrote: | Well done - all correct except 2 and these you actually explained correctly but gave the wrong answer!!
They relate to the sub-groups and the WHO classification.
G6PD levels are 'charactersitically' low
and
not all types are associated with low levels (they are normal in groups 4 and 5)
N |
Yeah, I knew perfectly well that type 4 is normal and type 5 is actually excessive...
| Quote: | | has five genetic variants all of which reflect the degree of deficiency |
.. I guess I just slept through ... remind me to read the stem properly!!   |
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cpeedahsa
Century Club
Joined: 21 Apr 2007
Posts: 922
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| Posted: Tue Sep 09, 2008 8:35 pm Post subject: |
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Acute haemolysis in patients with glucose-6-phosphate dehydrogenase deficiency (G6PD) may be precipitated by:
diabetic ketoacidosis-True
acute renal failure-True?
upper respiratory tract infection-True?
anti-malarial drugs -True (not all; although 30 mg weekly for 8 weeks has been found to be without undue harmful effects in African and Asian people )
sulfonamides -True ( not all; sulfadiazine tested and found not to be haemolytic in many with G6PD-deficiency )
methylene blue -True
aspirin -True
nitrofurantoin -True?
henna[/b]-True |
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cpeedahsa
Century Club
Joined: 21 Apr 2007
Posts: 922
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| Posted: Tue Sep 09, 2008 8:48 pm Post subject: |
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| Nick Raine-Fenning wrote: | Acute haemolysis in patients with glucose-6-phosphate dehydrogenase deficiency (G6PD) is characterised by:
The presence of Heinz bodies |
False--During and immediately after a hemolytic episode, tests may yield false-negative results because of destruction of the older, more deficient RBCs and the presence of reticulocytes rich in G6PD. |
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cpeedahsa
Century Club
Joined: 21 Apr 2007
Posts: 922
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| Posted: Tue Sep 09, 2008 8:54 pm Post subject: |
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| Nick Raine-Fenning wrote: | Acute haemolysis in patients with glucose-6-phosphate dehydrogenase deficiency (G6PD) is characterised by:
? Increased lactate dehydrogenase (LDH) which correlates with disease severity
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Again True |
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cpeedahsa
Century Club
Joined: 21 Apr 2007
Posts: 922
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| Posted: Tue Sep 09, 2008 8:55 pm Post subject: |
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| Nick Raine-Fenning wrote: | Acute haemolysis in patients with glucose-6-phosphate dehydrogenase deficiency (G6PD) is characterised by:
? An increased haptoglobin
? |
True[/b] |
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cpeedahsa
Century Club
Joined: 21 Apr 2007
Posts: 922
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| Posted: Tue Sep 09, 2008 8:55 pm Post subject: |
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| Nick Raine-Fenning wrote: | Acute haemolysis in patients with glucose-6-phosphate dehydrogenase deficiency (G6PD) is characterised by:
? A positive direct Coombs test
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False |
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cpeedahsa
Century Club
Joined: 21 Apr 2007
Posts: 922
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| Posted: Tue Sep 09, 2008 8:56 pm Post subject: |
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| Nick Raine-Fenning wrote: | Acute haemolysis in patients with glucose-6-phosphate dehydrogenase deficiency (G6PD) is characterised by:
A positive Beutler fluorescent spot test |
False
The Beutler fluorescent spot test -rapid , inexpensive test(identifies NADPH produced by G6PD under ultraviolet light). falsely negative in patients who are actively hemolysing.
done 2-3 weeks after a hemolytic episode. |
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Nick Raine-Fenning
Course Director
Joined: 27 May 2006
Posts: 1862
Location: Nottingham
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| Posted: Wed Sep 10, 2008 4:48 pm Post subject: |
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| cpeedahsa wrote: | G6PD levels are 'charactersitically' low -- so the answer to that question | Quote: | | is characterised by abnormally high levels of glucose-6-phosphate dehydrogenase |
is False as mentioned in my post ... right?
Or am I missing something
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No you miss nothing! Correct.
The rest of your answers on this page are also correct (incl nitrofurantoin) except one which relates to blood levles of various things during haemolysis?????? |
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