TEALE FENNING

docsubhi · Joined: 03 Sep 2007 Posts: 59 Location: london

Regarding dysgerminoma of ovary

Associated with raised Inhibin-A levels
Typically associated with raised AFP levels
Are radiosensistive
Are typically treated with radiotherapy
Are associated with gonadal dysgenesis
Are characterestically found in Turner's

I know most of thse are very easy questions
Interesting how "typically" and "characterestically" changes so many answers!

Evil or Very Mad

docsubhi · Joined: 03 Sep 2007 Posts: 59 Location: london

Associated with raised Inhibin-A levels
False (answer in the book)
But are associated with AFP,LDH,BHG,placental askphos (in metastatic disease). No true tumour marker
There are case reports of inhibin A/B being raised

Inhibin is a peptide hormone normally produced by ovarian granulosa cells. It reaches a peak in the follicular phase of the menstrual cycle and is undetectable in the serum of menopausal women. granulosa-cell tumors produce inhibin. Since serum inhibin levels reflect the size of the tumor, measurements of inhibin can be used as a marker for primary as well as recurrent disease

Typically associated with raised AFP levels
False
But can be raised

Are radiosensistive
True

Are typically treated with radiotherapy
False
Management dependent on staging. Radiotherapy not chosen as first line if surgery possible.

Are associated with gonadal dysgenesis True

Are characterestically found in Turner's
False

Any corrections??
Thanks

Surabhi

Maud · Joined: 11 Oct 2007 Posts: 73 Location: Bristol

I agree with all of Surabhi's true/false answers.

We agree that dysgerminoma's are not typically associated with raised AFP. I thought, however, that they were not associated with raised AFP AT ALL. e.a. CANNOT be raised in dysgerminoma's? Just raised in other germ cell tumours (endodermal sinus tumours and embryonal carcinoma's)?

I also didn't realize that dysgerminoma's were associated with gonadal dysgenesis, but guessed that answer was true. Is it true?
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Nick Raine-Fenning · Posted: Thu Aug 14, 2008 7:03 pm Post subject:

Surabhi is spot on.

The marker is LDH (raised in >95%) although hCG is raised in 3%

They are associated with gonadal dysgenesis which often coexists with a gonadoblastoma. This is one on my 'nasty' EMQs Smile

docsubhi · Joined: 03 Sep 2007 Posts: 59 Location: london

Those nasty EMQs helped !

Just finished reading the VTE in pregnancy guideline
am daydreaming EMQs !