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Dysfunctional uterine bleeding

 
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EMAK
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Joined: 26 Nov 2006
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PostPosted: Fri May 25, 2007 9:43 am    Post subject: Dysfunctional uterine bleeding Reply with quote

Practical tips

Dysfunctional uterine bleeding is a diagnosis of exclusion: other conditions such as uterine fibroids, endometrial polyps, and systemic diseases must be excluded by appropriate investigations

Tranexamic acid and mefenamic acid are among the most effective first line drugs for treating menorrhagia

Women needing contraception have a choice of combined oral contraceptive, levonorgestrel releasing intrauterine system, or long acting progestogens

Only 2% of endometrial carcinomas occur before age 40. Nulliparity, diabetes, obesity, and polycystic ovary syndrome are risk factors

Postmenstrual scans are often useful; the endometrium should be at its thinnest then, and polyps and cystic areas are more noticeable

====================================
Ref: BMJ
http://www.bmj.com/cgi/content/short/334/7603/1110?etoc
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Nick Raine-Fenning
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PostPosted: Fri May 25, 2007 3:13 pm    Post subject: Reply with quote

Not sure this is still true following the NICE Guideline on HMB.

The info (aimed at GPs) mentions this document is 'due' so is out of date.

Primary treatment is now the Mirena!

Have a read of this link where we have briefly started to discuss the new Guideline.
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EMAK
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PostPosted: Fri May 25, 2007 3:56 pm    Post subject: Reply with quote

Quote:
Primary treatment is now the Mirena!

Really? Exclamation Exclamation even before simple medical treatment like mefenamic acid and Cyclocapron ? Exclamation Exclamation
Actually I recieve this BMJ article just today.
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Nick Raine-Fenning
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PostPosted: Fri May 25, 2007 4:08 pm    Post subject: Reply with quote

Yes Shocked

Read the NICE Guideline.
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cpeedahsa
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PostPosted: Fri May 25, 2007 4:44 pm    Post subject: Reply with quote

Quote:
Pharmaceutical treatment
• If history and investigations indicate that pharmaceutical treatment is appropriate and either hormonal or non-hormonal treatments are acceptable, treatments should be considered in the following order:
*levonorgestrel-releasing intrauterine system (LNG-IUS) provided long-term (at least 12-months) use is anticipated
*levonorgestreltranexamic acid or non-steroidal anti-inflammatory drugs (NSAIDs) or combined oral contraceptives (COCs)
*levonorgestrelnorethisterone (15 mg) daily from days 5 to 26 of the menstrual cycle, or injected long-acting progestogens.
• If hormonal treatments are not acceptable to the woman, then either tranexamic acid or NSAIDs can be used.


Thi is current stand from NICE on HMB
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cpeedahsa
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PostPosted: Fri May 25, 2007 4:47 pm    Post subject: Reply with quote

http://www.nice.org.uk/page.aspx?o=CG044

This is the link to the NICE guideline on HMB
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cpeedahsa
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PostPosted: Fri May 25, 2007 4:58 pm    Post subject: Reply with quote

and also this

http://www.nice.org.uk/CG044quickrefguide
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EMAK
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PostPosted: Sat May 26, 2007 6:53 am    Post subject: Reply with quote

Thanks a lot
I read it previuosly and I review it with the forum and with Nick advice.
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rpwalavalkar
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Joined: 20 Jul 2006
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PostPosted: Thu Sep 04, 2008 6:44 am    Post subject: Reply with quote

a quick reference list for causes guys, please add or debate causes that you don't agree with ---

ovulatory

hypothyroidism / hyperthyroidism

drug induced/medication side effects (coumadin, ASA, steroids)

coagulation disorders --

Idiopathic thrombocytopenia / septicemic thrombocytopenia / immunologic thrombocytopenia

hereditary clotting factor abnormalities --
factor VIII deficiency (von Willibrand's disease)
factor XI deficiency (Rosenthal's syndrome)
factor V deficiency (Owren's disease)
factor VII deficiency
factor X deficiency (Stuart factor deficiency)
prothrombin deficiency and dysfibrinogenemia


liver cirrhosis
hepatitis

trauma/foreign bodies

infection
severe vaginal infection (trichomonas, bacterial vaginitis, yeast)
cervicitis


anovulatory with atrophic endometrium

contraceptive associated -- DMPA / OCP / POP / Implant

increased prolactin --
pituitary prolactinoma
hyperprolactinemia
other pituitary tumors
empty sella syndrome
growth hormone excess - acromegally
Nelson's syndrome
pseudotumor cerebri

chronic renal failure/hemodialysis
persistant postpartum amenorrhea-galactorrhea
chronic systemic disease


anovulatory with proliferative/hyperplastic endometrium

stress-related
polycystic ovarian syndrome
hyperandrogenism/insulin resistance
adrenogenital syndrome
Cushing's syndrome
hypothyroidism
obesity
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