TEALE FENNING

farha · Century Club Joined: 18 May 2007 Posts: 144

DES EXPOSURE in pregnencyIS ASSOCIATED WITH

1)Uterine abnormalities in ithe female offspring.
2)assocted withreduced pregnency rate.
3)an increased incidence ofhypertensive disorder.
4)oligozoospermia in themale offspring.

salihabduallah · Joined: 04 Sep 2007 Posts: 94

DES EXPOSURE in pregnencyIS ASSOCIATED WITH

1)Uterine abnormalities in ithe female offspring. TRUE
2)assocted withreduced pregnency rate. FALSE
3)an increased incidence ofhypertensive disorder. FALSE
4)oligozoospermia in themale offspring. FALSE

THE LAST ONE I'M NOT SURE ABOUT IT.

farha · Century Club Joined: 18 May 2007 Posts: 144

You are right salih that stem 1 is TRUE as thereare UTERINE abnormalities which include classically hypoplastic T shaped uterus and occurs in 69%
STEM 2 is FALSE AS pregnency rate is not effected howwever ECTOPIC PREGNENCY rate is 10 fold

stem 3 is definately FALSE as there is no asssociation linked to it
stem 4 I m also doubt ful because I read that it does efffect quality of SEMEN but effect on sperm no is not known and according to RCOG statement it does reduce male fertility but how , it is not mentioned .Any body else can throw some light?

rpwalavalkar · Teale Fenning Administrator Joined: 20 Jul 2006 Posts: 918

hi farah,

coming back to stem 4. I'll go with TRUE.

Undescended testicles or abnormally small testicles have been found in male fetus with in-utero DES exposure. No conclusive data about risk for testicular or prostate cancer is available. Data is also inconclusive about urogenital abnormalities in male off springs.

[ ref -- National Cancer Institute. DES Research Update 1999: Current Knowledge, Future Directions. National Cancer Institute, 1999. ]

Small testicles and undescended testis are associates with oligozoospermia, DES causes small and undescended testicles, and hence I go with true.

r
_________________
Dr Miss. Raj Walavalkar MBBS MRCOG
TealeFenning Administrator
SpR O&G Wessex Region

Nick Raine-Fenning · Posted: Wed Jun 04, 2008 10:51 am Post subject:

I spent a long time researching stem 4 and have to admit that I am still confused.

It is definitely associated with hypoplastic testes and cryporchidism but according to several reports and key texts, not oligospermia. In my experience the former testicle problems are almost always associated with some abnormality in the seminal fluid analysis so I expected it would also reduce male fertility but could not find this anywhere.

N

rpwalavalkar · Teale Fenning Administrator Joined: 20 Jul 2006 Posts: 918

what do you suggest we go with then nick?
_________________
Dr Miss. Raj Walavalkar MBBS MRCOG
TealeFenning Administrator
SpR O&G Wessex Region

Nick Raine-Fenning · Posted: Wed Jun 04, 2008 2:53 pm Post subject:

A somewhat unconvincing False

docsubhi · Joined: 03 Sep 2007 Posts: 39 Location: london

Male fertility
There appears to be some evidence from one study in the USA of a possible reduction of male
fertility. The long-term UK study showed a correlation between single status and higher dose exposure earlier in pregnancy implying a possible interference with sexual function.

http://www.cancerscreening.nhs.uk/rcog-statement-no2.pdf

Just reading the guideline - and forgot what the consensus was on the course ... True???

Nick Raine-Fenning · Posted: Wed Aug 13, 2008 8:11 am Post subject:

yes - false; cryporchidism but not oligospermia.

Not sure I personally believe this but my opinion is unimportant.

The key here is that DES is associated with structural abnormalities of the reproducitve tract in both males and females.