TEALE FENNING

Xerxes I · Posted: Mon Dec 31, 2007 1:55 pm Post subject: CEA and ovarian cancer

CEA is elevated in approximately 34–37% of the patients with ovarian cancer and more often in mucinous (88%) than in non-mucinous (19%) cancers (Bast et al. 1984, Tholander et al. 1990, Stenman et al. 1995, Tuxen et al. 1995).

This was asked in one of the past paper MCQs (Sep 2001)

rpwalavalkar · Teale Fenning Administrator Joined: 20 Jul 2006 Posts: 966

hi xerxes I,

nice to have u back.

u are right it is raised in about 35% of the cases ( just looked it up)

r
_________________
Dr Miss. Raj Walavalkar MBBS MRCOG
TealeFenning Administrator
SR O&G Wessex Region

Xerxes I · Posted: Sat Apr 05, 2008 2:13 pm Post subject:

I think I read somewhere Musinous epithelian CA has cells similar to endocervix and Serous has cells similar to Fallopian tube mucosa.

rpwalavalkar · Teale Fenning Administrator Joined: 20 Jul 2006 Posts: 966

hi xerxes I,

u are right..

Mucinous tumors histologically resemble endocervical epithelium. Primary ovarian mucinous tumors can be difficult to distinguish from metastatic mucinous tumors from the colon/rectum, appendix, cervix, or pancreas.

ref --

Scully, RE, Young, RH, Clement, PB. Mucinous tumors and pseudomyxoma peritonei. In: Tumors of the Ovary, Maldeveloped Gonads, Fallopian Tube, and Broad Ligament, Armed Forces Institute of Pathology, Washington, DC, 1998. p.81.

Seidman, JD, Ronnett, BM, Kurman, RJ. Pathology of borderline (low malignant potential) ovarian tumours. Best Pract Res Clin Obstet Gynaecol 2002; 16:499.

Khunamornpong, S, Suprasert, P, Pojchamarnwiputh, S, et al. Primary and metastatic mucinous adenocarcinomas of the ovary: Evaluation of the diagnostic approach using tumor size and laterality. Gynecol Oncol 2006; 101:152.

Seidman, JD, Kurman, RJ, Ronnett, BM. Primary and metastatic mucinous adenocarcinomas in the ovaries: incidence in routine practice with a new approach to improve intraoperative diagnosis. Am J Surg Pathol 2003; 27:985.
_________________
Dr Miss. Raj Walavalkar MBBS MRCOG
TealeFenning Administrator
SR O&G Wessex Region

rpwalavalkar · Teale Fenning Administrator Joined: 20 Jul 2006 Posts: 966

The histological pattern of serous tumors of the ovary simulates the lining of the fallopian tube.
Poorly differentiated forms of serous carcinomas are grossly indistinguishable from other epithelial tumors. This histologic variant is often associated with concentric rings of calcification known as psammoma bodies.

ref --

Ben-Baruch, G, Sivan, E, Moran, O, et al. Primary peritoneal serous papillary carcinoma: a study of 25 cases and comparison with stage III-IV ovarian papillary serous carcinoma. Gynecol Oncol 1996; 60:393.

Scully, RE, Young, RH, Clement, PB. Surface epithelial-stromal tumors and serous tumors. In: Tumors of the Ovary, Maldeveloped Gonads, Fallopian Tube, and Broad Ligament, Armed Forces Institute of Pathology, Washington, DC, 1998. p.51.
_________________
Dr Miss. Raj Walavalkar MBBS MRCOG
TealeFenning Administrator
SR O&G Wessex Region

Xerxes I · Posted: Tue Apr 15, 2008 4:21 pm Post subject:

Just to add something about the Psammoma bodies.
These are one of the reasons we think there is an element of invagination of the ovarian epithelium. these bodies are concentric calcium deposits and are seen in other tumors like papillary thyroid ca, meningioma, etc.