TEALE FENNING

anaghawalavalkar · Joined: 06 Apr 2008 Posts: 5 Location: Republic of Ireland

causes of vulval carcinoma include--- T/F

1. malignant melanoma
2. chronic bartholins gland infection
3. HSV
4. lichen sclerosus
5. lichen planus
6. HPV
_________________
Dr Anagha Walavalkar

Xerxes I · Posted: Tue Apr 08, 2008 4:21 pm Post subject:

causes of vulval carcinoma include--- T/F

1. malignant melanoma
2. chronic bartholins gland infection
3. HSV
4. lichen sclerosus
5. lichen planus
6. HPV

Not very comfortable with the word "causes" but would go for
TFFTTT
but most of these are associations and not causes. malignant melanoma IS a form of skin cancer and does not "cause" it.

rpwalavalkar · Teale Fenning Administrator Joined: 20 Jul 2006 Posts: 966

vulval Ca and HSV infection --- have found following references and hence going for True

1.
M Madeleine, J Daling, J Carter, G Wipf, S Schwartz, B McKnight, R Kurman, A Beckmann, M Hagensee, D Galloway. Cofactors With Human Papillomavirus in a Population-Based Study of Vulvar Cancer. Journal of the National Cancer Institute, Vol. 89, No. 20, October 15, 1997

2.
Melnick JL, Dreesman GR, Adam E, Kaufman R. The role of herpes simplex virus in cervical and vulvar cancer. Dev Biol Stand. 1982;52:87-94.

3.
Kaufman RH, Dreesman GR, Burek J, Korhonen MO, Matson DO, Melnick JL, Powell KL, Purifoy DJ, Courtney RJ, Adam E. Herpesvirus-induced antigens in squamous-cell carcinoma in situ of the vulva.
_________________
Dr Miss. Raj Walavalkar MBBS MRCOG
TealeFenning Administrator
SR O&G Wessex Region

Xerxes I · Posted: Tue Apr 15, 2008 12:25 pm Post subject:

I'm not sure you can assume a causative relationship based on these references. all they show is either presence of or a weak correlation.

A correlation between presence of HPV and HSV is not surprising at all as they are both STDs and are transmitted with by the same vehicle Laughing

if you can call it that Twisted Evil

I'd say it is not a know cause even if somebody said it is in "Dev Biol Stand. 1982" Twisted Evil

cpeedahsa · Century Club Joined: 21 Apr 2007 Posts: 921

cpeedahsa · Century Club Joined: 21 Apr 2007 Posts: 921

Cancer research UK-Vulval Ca

Click here : Vulva Cancer risk factors

HPV -present in a proportion of vulval tumours, and HPV 16 is the most commonly detected type.

70% of in situ vulval squamous cell carcinoma (SCC) contain HPV DNA, while the detection rate of HPV DNA in invasive vulval SCC is 20–50%.

HPV is most strongly linked with tumours in younger women, with an 11-fold risk increase reported for vulval intraepithelial neoplasia (VIN) and early-stage cancer in women under the age of 45 with serological evidence of HPV infection, but no increase in women over this age.

Women with a previous cervical cancer or cervical intraepithelial neoplasia grades 3–5 have up to a ten-fold increased risk for vulval cancer.

Increased risks have also been reported for women diagnosed with cancers at other anogenital sites, or with a family history of anogenital cancer.

Genital warts (associated with infection with HPV 6 and HPV 11) increase risk for vulval cancer.

Increased risk is also reported for individuals with a prior SCC of the skin, which may be related to HPV infection.

Presence of antibodies to the herpes simplex virus type 2 in blood samples is associated with an increased risk of vulval cancer and pre-cancer, after HPV infection is controlled for.

There is an increased risk for vulval cancer and pre-cancers in HIV-positive women, with a particularly strong relationship for women under the age of 30.

There is a well-documented association between smoking and risk of vulval SCC, with reported six-fold and three-fold risk increases in current smokers for in situ and invasive tumours, respectively.

Risk increases with greater intensity and number of years of smoking and remains elevated more than five years after cessation.There is a likely interaction between cigarette smoking and HPV infection in risk of vulval cancer, with a 25-fold risk increase reported for women smoking 20 or more cigarettes a day who also have serological evidence of HPV 16 infection.

Incidence of vulval cancer has been shown to be increased 100-fold following renal transplants.