TEALE FENNING Medical Education    FAQ   Search   Memberlist   Usergroups   Register   Profile   Log in to check your private messages   Log in  mrcog courses for doctors Causes of Amenorrhoea          TEALE FENNING Forum Index -> Key Facts in O&G View previous topic :: View next topic   Author Message rpwalavalkar Teale Fenning Administrator Joined: 20 Jul 2006 Posts: 966 Posted: Fri Sep 22, 2006 5:19 pm    Post subject: Causes of Amenorrhoea Hi all, i am reasonably sure the list is complete, do suggest additions/deletions if any....... Generalized pubertal delay Constitutional delay Hypergonadotropic hypogonadism Turner syndrome Gonadal dysgenesis with mosaic karyotype Pure gonadal dysgenesis (Perrault syndrome, Swyer syndrome) Gonadotropin-resistant ovary syndrome Acquired causes high-dose alkylating chemotherapy pelvic radiation autoimmune oophoritis Hypogonadotropic hypogonadism Chronic conditions starvation excessive exercise depression psychological stress marijuana use Crohn disease cystic fibrosis sickle cell disease thalassemia major HIV infection renal disease thyroid disease diabetes mellitus anorexia nervosa etc. Slow-growing CNS tumors adenomas craniopharyngiomas meningiomas pituitary microadenomas Abnormal hypothalamic development Kallmann syndrome Prader-Willi syndrome Laurence-Moon-Biedl-Bardet syndrome Acquired miscellaneous disorders infiltration disorders --- sarcoidosis, Langerhans cell histiocytosis, syphilis, tuberculomas ischemia disorders --- trauma, aneurysm, obstruction of the aqueduct of Sylvius destruction --- concentrated, high-dose exposure to radiation Normal puberty Associated with hyperandrogenicity PCO syndrome late-onset 21-hydroxylase deficiency immaturity of the hypothalamic-pituitary-ovarian axis Cushing disease androgen-producing ovarian or adrenal tumors ovarian stromal hypertrophy Normal puberty Associated with absence of hirsutism or virilization immaturity of the hypothalamic-pituitary-ovarian axis pregnancy Hypergonadotropic hypogonadism ovarian failure high-dose alkylating chemotherapy pelvic radiation autoimmune oophoritis Anomalies of the genital tract Müllerian agenesis -- Mayer-Rokitansky-Kuster-Hauser syndrome ( breast present ) Congenital or acquired anatomic obstruction-- imperforate hymen transverse vaginal septum Asherman syndrome Androgen insensitive syndrome _________________ Dr Miss. Raj Walavalkar MBBS MRCOG TealeFenning Administrator SR O&G Wessex Region Back to top Nick Raine-Fenning Course Director Joined: 27 May 2006 Posts: 1852 Location: Nottingham Posted: Fri Sep 22, 2006 7:27 pm    Post subject: Hi Raj Great list - thanks. I'll have a closer look and reference this against what I have. We need to convert this into an essay or two and an EMQ. Should be easy to do. For the EMQ we simply need to write some clinical scenarios that relate to each disease. For the Essay we need to generate some simple paragraphs that describe the clincial features of each condition and then outline which investigations are indicated and the appropriate management of each. Doing this way will actually help with the EMQ as well - they are actually very similar things. _________________ "Teale Fenning Medical Education" delivering evidence-based, exam-orientated learning since 1997 Back to top rpwalavalkar Teale Fenning Administrator Joined: 20 Jul 2006 Posts: 966 Posted: Thu Sep 04, 2008 6:55 am    Post subject: a few additions to the causes -- Hypergonadotropic hypogonadism (high FSH, low estradiol) gonadal dysgenesis -- 45 XO (Turner's syndrome) 46 XY (Swyer syndrome) 46 XX (familial gonadal dysgenesis) 17-à-hydroxylase deficiency galactosemia ataxia telangiectasia myotonia dystrophica autoimmune disorders resistant ovary syndrome _________________ Dr Miss. 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