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Blood transfusion in obstetrics

 
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Maud



Joined: 11 Oct 2007
Posts: 73
Location: Bristol

PostPosted: Tue Aug 19, 2008 2:29 pm    Post subject: Blood transfusion in obstetrics Reply with quote

Obstetric conditions associated with the need for blood transfusion may lead to morbidity and mortality if not corrected correctly.

A. How may the incidence of needing to give banked blood be reduced? (6)
B. What are the risks of transfusing banked blood products and how may they be reduced? 8
C. What blood products can be used in major obstetric haemorrhage and when is their use indicated? (6)
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Nick Raine-Fenning
Course Director


Joined: 27 May 2006
Posts: 1854
Location: Nottingham

PostPosted: Tue Aug 19, 2008 3:36 pm    Post subject: Reply with quote

Nice and not a bad 'spot' Maud. I would add a small bit on women who refuse / decline blood products as this has come up in the last 2 Confidential Enquiries although I appreciate this is detracting from the focus of your question. Might be best to ignore me and add my suggestion to a PPH or a MOH question Rolling Eyes I'll get my coat ... Cool
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Xerxes I
Century Club


Joined: 01 Mar 2007
Posts: 228
Location: Winchester

PostPosted: Sat Aug 23, 2008 1:41 pm    Post subject: Reply with quote

Obstetric conditions associated with the need for blood transfusion may lead to morbidity and mortality if not corrected correctly.

A. How may the incidence of needing to give banked blood be reduced? (6)
Primary Prevention of anaemia in the community!
Preconception visit FBS and treat if low
In unplanned, see at booking and religiously treat
Repeat in 2 weeks and if no respond, think again, consider parenteral in the absence of haemoglobinopathies and if not compliant

Active mangement of third stage
early intervention for PPH, use of drugs early

Operations
Reduction of section rate will probably haev a beneficial effect
If expecting more than 1500 ml, consider cell salvage
Done by appropriately trained,
Improve surgical skills
In some cases, siting uterine artery probes by the radiologist may have a role to do embolisation intraoperatively

Decision in conjunction with anaesthetist
Adherence to evidence-based protocols
Audit the amount used, indications etc



B. What are the risks of transfusing banked blood products and how may they be reduced? 8
giving the wrong blood is the most common and potentially very serious
Adherence to protocols, checklists, checking and double checking by two people
Incident reporting, audit
Some suggest (do they?) deferring Tx if possible until daytime to reduce clinical mistakes

Transmission of viral infection
Addressed at national level
using sensitive testing
considering window period

Other complications, not sure but maybe hyperkalemia, pulmonary oedema, volume overload, hypothermia,

C. What blood products can be used in major obstetric haemorrhage and when is their use indicated? (6)1
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Angel



Joined: 13 Jul 2008
Posts: 1
Location: London

PostPosted: Sat Aug 23, 2008 8:41 pm    Post subject: Reply with quote

I would add ;
Dietry advice at booking particularly for vegetarians
Check full blood count and antibody at 28 week and then 36 weeks.This is particulary important for women at risk of PPH(eg; multiparous women, H/O Previous PPH).
consider parentral iron therapy for women who are unable to take oral iron.
Autologous transfusion is not recommended in obstetric practice as women may not be able to increas their haemoglobin to original level by delivery.
Cell salvage has limited place in obstetrics due to potential risk of amniotic/fetal contaminatns and shold only be used in unit with previous experience.
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Maud



Joined: 11 Oct 2007
Posts: 73
Location: Bristol

PostPosted: Thu Aug 28, 2008 5:11 pm    Post subject: Reply with quote

Ok, here then finally my marking scheme:

A. How may the incidence of needing to give banked blood be reduced? (6)

Screen for anaemia at booking and in third trimester. Exclude haemoglobinopathies. If haemoglobinapathy, treat with advice from haematologist. Otherwise, oral iron preparations. Consider the use of parenteral iron iforal not tolerated, not absorbed or if no compliance. (2)

Angel wrote:
I would add ;

Autologous transfusion is not recommended in obstetric practice


Indeed, important "negative". (1 point)

Minimize bleeding by identifying women at high risk, advising on an active third stage and optimal management of haemorrhage with drugs, surgical intervention and early senior obstetric input. (2)

Consider cell salvage if loss > 1500 ml. (1)

B. What are the risks of transfusing banked blood products and how may they be reduced? 8

Infection,
Risk reduced by using CMV negative red cells & platelets. Also blood products tested for HIV and hepatitis. (1)

Red cell alloimmunisation. (1)
Risk reduced by using Kell negative blood when transfusing women of childbearing age. (1)
In pregnancy, G&S should be no more than 7 days old, as antibodies may have developed. (1)
Use group-specific blood if antibody negative.Full X-match if antibodies present. Use of O Rhesus negative blood in extreme situation. (1)
FFP, cryo and platelets should ideally be of the same group. Anti-D should be given if Rh+ platelets are given to a Rhesus- woman(1)

Receiving incorrect blood complement. Risk reduced by correct sampling & labelling and adherence to administration protocols, including double checking. (2)

C. What blood products can be used in major obstetric haemorrhage and when is their use indicated? (6)

Red cells: There are no firm criteria and decision is based on clinical and haematological grounds and the individual's age, medical history and symptoms. Transfusion is rarely indicated in the stable patient when Hb is greater than 10 g/dl and is almost always indicated when the Hb is less then 6 g/dl. (3)

Fresh Frozen Plasma, cryoprecipitate and platelets should not be given on clinical suspicion alone, unless there is delay in obtaining blood results. Use should be guided by coagulation tests and the advice of the haematologist. (1)
They are indicated in the bleeding woman with disseminated intravascular coagulation. Fibrinogen levels should be kept above 1.0 g/l by use of FFP. (1)

Recombinant factor VIIa may be considered for life-threatening haemorrhage, after discussion with the haematologist, but should not be a substitute for or delay life-saving procedures. (1)
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Maud



Joined: 11 Oct 2007
Posts: 73
Location: Bristol

PostPosted: Thu Aug 28, 2008 5:14 pm    Post subject: Reply with quote

[quote="Xerxes I"]
giving the wrong blood is the most common and potentially very serious [quote="Xerxes I"]

I like!
Probably would have earned an extra point..
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