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EMAK
Century Club
Joined: 26 Nov 2006
Posts: 572
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 Posted: Tue Nov 28, 2006 4:46 pm Post subject: Anti-infective agents |
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Agent that are contra-indicated in the third trimister:
-chloramphenecol.......T
-metronidazole...........F
-acyclovir..................F |
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rpwalavalkar
Teale Fenning Administrator
Joined: 20 Jul 2006
Posts: 973
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| Posted: Tue Nov 28, 2006 7:22 pm Post subject: |
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hi,
i agree with your answers.
chloramphenicol --- T
Use is not recommended in pregnancy at term or during labor because of potential toxicity of gray baby syndrome or bone marrow depression, in infants especially premature.
Gray syndrome = neonatal hepatic enzymes system is not mature enough to metabolize chloramphenicol appropriately. Hence it accumulates in the baby's blood stream, causing hypotension , cyanosis, leading to death.
metronidazole --- F
acyclovir --- F
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Dr Miss. Raj Walavalkar MBBS MRCOG
TealeFenning Administrator
SR O&G Wessex Region |
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Nick Raine-Fenning
Course Director
Joined: 27 May 2006
Posts: 1862
Location: Nottingham
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| Posted: Wed Nov 29, 2006 7:55 am Post subject: |
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You may be surprised to hear that metronidazole is contraindicated in the first trimester - see the BNF!
I know we use it but it is not recommended and we advise avoidance. |
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rpwalavalkar
Teale Fenning Administrator
Joined: 20 Jul 2006
Posts: 973
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| Posted: Wed Nov 29, 2006 9:45 am Post subject: |
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hi nick,
agree with you about metro and first trim.
the mcq stem says third trim. hence i answered 'F'
raj
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Dr Miss. Raj Walavalkar MBBS MRCOG
TealeFenning Administrator
SR O&G Wessex Region |
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Nick Raine-Fenning
Course Director
Joined: 27 May 2006
Posts: 1862
Location: Nottingham
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| Posted: Wed Nov 29, 2006 10:08 am Post subject: |
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That will teach me to read the question!!
You are absolutely right - metronidazole is safe in trimester 2 and 3. |
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mridulaben
Century Club
Joined: 08 Nov 2006
Posts: 137
Location: Brunei
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| Posted: Thu Dec 14, 2006 5:37 am Post subject: |
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Some of recent studies say MNZ is not Contraindicated even in first trimester. I Do not remember where i read. But caution is required i suppose. I do not know whether to answer T or F.
Mri |
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Nick Raine-Fenning
Course Director
Joined: 27 May 2006
Posts: 1862
Location: Nottingham
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| Posted: Thu Dec 14, 2006 9:10 am Post subject: |
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It is definitely false as it is the third trimester
I would be surprised if they had this question in the first trimester as it is debatable but if they did I would answer false if it said 'absolutely contraindicated' and true if it said 'relatively contraindicated' or 'best avoided'.
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