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Amenorrhea due to abn hypothalamic-pituitary-ovarian axis

 
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cpeedahsa
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Joined: 21 Apr 2007
Posts: 922

PostPosted: Fri Aug 31, 2007 11:45 pm    Post subject: Amenorrhea due to abn hypothalamic-pituitary-ovarian axis Reply with quote

Major causes of amenorrhea due to abnormalities in the hypothalamic-pituitary-ovarian axis Abnormality Causes

Hypothalamic dysfunction
    Functional hypothalamic amenorrhea-Weight loss, eating disorders , Exercise , Stress ,Severe or prolonged illness
    Congenital gonadotropin-releasing hormone deficiency
    Inflammatory or infiltrative diseases
    Brain tumors - eg, craniopharyngioma
    Pituitary stalk dissection or compression
    Cranial irradiation
    Brain injury - trauma, hemorrhage, hydrocephalus
    Other syndromes - Prader-Willi, Laurence-Moon-Biedl


Pituitary dysfunction
    Hyperprolactinemia
    Other pituitary tumors - acromegaly, corticotroph adenomas (Cushing's disease)
    Other tumors - meninigioma, germinoma, glioma
    Empty sella syndrome
    Pituitary infarct or apoplexy


Ovarian dysfunction Ovarian failure (menopause) :Spontaneous , Premature (before age 40 years) , Surgical

Other
    Hyperthyroidism
    Hypothyroidism
    Diabetes mellitus
    Exogenous androgen use
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