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Alpha Methyl dopa

 
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cpeedahsa
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PostPosted: Fri Jun 01, 2007 1:03 am    Post subject: Alpha Methyl dopa Reply with quote

1)Alpha Methyl dopa is licensed for use in the UK as antihypertensive in pregnancy. T/F

Answer- False


Last edited by cpeedahsa on Mon Jun 04, 2007 4:51 am; edited 1 time in total
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rpwalavalkar
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PostPosted: Fri Jun 01, 2007 5:01 pm    Post subject: Reply with quote

T
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EMAK
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PostPosted: Sat Jun 02, 2007 2:55 am    Post subject: Reply with quote

True>>>not very sure about max. dose but can be 3 g/day,,,
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Nick Raine-Fenning
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PostPosted: Sat Jun 02, 2007 9:14 am    Post subject: Reply with quote

Thought you could go up to 4g??
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rpwalavalkar
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PostPosted: Sat Jun 02, 2007 10:34 am    Post subject: Reply with quote

The maximum dosage is 65 mg/kg or 3 g daily which ever is more.

use with caution if on --
ACE Inhibitors -- potentiates effect
Beta-blockers -- potentiates effect
Calcium-channel blockers -- potentiates effect
Viagra® or other PDE-5 inhibitors -- ??
NSAIDs – may reduce antihypertensive efficacy


can cause hemolytic anemia
can cause jaundice

r
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cpeedahsa
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PostPosted: Mon Jun 04, 2007 4:38 am    Post subject: Reply with quote

http://cks.library.nhs.uk/hypertension_in_pregnancy/view_whole_guidance

Methyldopa is not licensed to be used in pregnancy!
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cpeedahsa
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PostPosted: Mon Jun 04, 2007 4:40 am    Post subject: Reply with quote

http://cks.library.nhs.uk/hypertension_in_pregnancy/view_whole_guidance

Nifedipine is not licensed either for use in pregnancy as a antihypertensive


Last edited by cpeedahsa on Mon Jun 04, 2007 4:52 am; edited 1 time in total
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cpeedahsa
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PostPosted: Mon Jun 04, 2007 4:45 am    Post subject: Reply with quote

http://cks.library.nhs.uk/hypertension_in_pregnancy/view_whole_guidance

Labetalol is licensed!

I was not able to find info on Hydrallazine though
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cpeedahsa
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PostPosted: Mon Jun 04, 2007 4:50 am    Post subject: Reply with quote

There is a letter in BJOG 2004 that mentions that magnesium sulphate in pre-eclampsia is not licensed for use in preeclampsia!!! However I am not able to find other references.

Here is the link to that letter !
http://www.blackwell-synergy.com/action/showPdf?submitPDF=Full+Text+PDF+%2854+KB%29&doi=10.1111%2Fj.1471-0528.2004.00118.x

BJOG: April 2004, Vol. 111, pp. 392
The drugs we deserve
Bryony Jones, Aarthi Mohan & Phillip Bennett
Imperial College Parturition Research Group, UK
Faculty of Medicine, Imperial College London, UK
Institute of Reproductive and Developmental Biology, Queen
Charlottes and Chelsea Hospital, Du Cane Road, London W120NN, United Kingdom
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farha
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PostPosted: Mon Jun 04, 2007 6:49 am    Post subject: METHYL DOPA Reply with quote

What is the consensus LICENSED OR NOT LISENSED? Confused
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rpwalavalkar
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PostPosted: Mon Jun 04, 2007 9:07 pm    Post subject: Reply with quote

farah,

i really don't think licensing is a big issue, max it will carry is 1 mark worth of mcq. you can cover 3 mcq marks with one essay mark. remember what you can, what you can't won't matter much.

licensed or not, don't forget the drugs that we do use and why we use them.

cheers

raj


p.s -- by the way methyldopa -- not licensed, the nhslibrary reference says so and i'll go with it.
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cpeedahsa
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PostPosted: Mon Jun 04, 2007 9:21 pm    Post subject: Reply with quote

I guess irrespective of whether the drug is licensed or not, some drugs are going to used simply because some/most of them are effective in clinical practice. (or sometimes for other reasons).

It only makes it a little bit more interesting to know that bit about license. Moreover MCQs make learning more fun.

I suppose the exam maybe structured in such a way that MCQs and EMQs are less important than essays; but I do know people have passed in the essays and failed because of MCQs!

Maybe simply mastering the essay technique helps a lot to just pass the exam, but knowing more won't hurt at all and is infact useful post exams, in practice. At the same time, I agree, being exam oriented helps with passing the exams.
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wolverine
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PostPosted: Tue Jun 05, 2007 2:01 am    Post subject: Reply with quote

About liscensing though I would agree with Raj. I can't remember hardly any MCQ's I did when I was preparing referred to if something is liscenced or not and there was not any in the exams in March. And at the end of the day what it really matters is what is been evidenced to be effective (i.e. antenatal steroids not liscenced (?yet)) and NOT what is liscenced both for the exams and for my practice!!
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wolverine
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PostPosted: Tue Jun 05, 2007 2:05 am    Post subject: Reply with quote

I agree that sometimes drugs are used for "other" reasons but I know that some other drugs are not liscenced for "other" reasons too
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rpwalavalkar
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PostPosted: Tue Jun 05, 2007 8:37 am    Post subject: Reply with quote

well put vangelis, you have said exactly what i meant to....

r
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